Product Name :
eIF4A3 Recombinant Rabbit Monoclonal Antibody [JG35-33]
Predicted band size :
Observed band size :
Synonyms:
ATP-dependent RNA helicase DDX48 antibody ATP-dependent RNA helicase eIF4A-3 antibody DDX48 antibody DEAD box protein 48 antibody eIF-4A-III antibody eIF4A-III antibody EIF4A3 antibody eIF4AIII antibody Eukaryotic initiation factor 4A-III antibody Eukaryotic initiation factor 4A-like NUK-34 antibody 展开
Function :
ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD).939793-16-5 manufacturer Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation.3-Methyloxazolidine-2,5-dione Chemical name
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within N-terminal Human eIF4A3 .
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P, FC, IF-Cell, IF-Tissue, IP
Coupling :
unconjugated
Clone number:
JG35-33
RRID:
AB_3070812
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33439569 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 47 kDa
Positive control :
SiHa cell lysates, LOVO, MCF-7, SiHa, human tonsil tissue, human colon carcinoma, human prostate cancer tissue, mouse skin tissue, rat skin tissue, human lymph nodes tissue.