Product Name :
FAM38A/PIEZO1 Mouse Monoclonal Antibody [2-10]
Predicted band size :
287 kDa
Observed band size :
287 kDa
Synonyms:
DHS Fam38a Family with sequence similarity 38 member A KIAA0233 Membrane protein induced by beta-amyloid treatment Mib PIEZ1_HUMAN Piezo-type mechanosensitive ion channel component 1 PIEZO1 Protein FAM38A 展开
Function :
Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation.4-Bromothiazolo[5,4-c]pyridin-2-amine Purity Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Recombinant protein within Human Protein FAM38A aa 1275-1540 / 2521.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IHC-P
Coupling :
unconjugated
Clone number:
2-10
RRID:
AB_3073014
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
Store at +4℃ after thawing.BuyBis(4-methoxybenzyl)amine Aliquot store at -20℃ or -80℃.PMID:33749492 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG2a
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 287 kD
Positive control :
MCF-7, Hela, Siha, A431, mouse brain tissue, rat brain tissue, rat hippocampus tissue.