Product Name :
SCIN Recombinant Rabbit Monoclonal Antibody [JE62-89]
Predicted band size :
80 kDa
Observed band size :
80 kDa
Synonyms:
Adseverin antibody ADSV_HUMAN antibody KIAA1905 antibody Scin antibody Scinderin antibody
Function :
Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles. Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts. Regulates chondrocyte proliferation and differentiation. Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within Human SCIN aa 616-715 / 715.Buy1445-55-2
Species reactivity:
Human, Mouse, Rat
Verify application:
WB
Coupling :
unconjugated
Clone number:
JE62-89
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Thiol-C2-PEG2-OH Chemical name Aliquot store at -20℃.PMID:33677996 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 80 kDa
Positive control :
HEK-293 cell lysate, NIH/3T3 cell lysate, Mouse kidney tissue lysate, Rat kidney tissue lysate.